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Medically Reviewed

What is the M367 Pill?

- 12 sections

All of the information on this page has been reviewed and verified by a certified addiction professional.

The M367 pill is a white, oblong tablet with the imprint “M367” clearly stamped on one side.

It’s a combination prescription medication that contains hydrocodone bitartrate (10 mg) and acetaminophen (325 mg), a powerful opioid pain reliever paired with a commonly used over-the-counter analgesic.

While this medication is often prescribed for moderate to severe pain, such as post-surgical pain, it also comes with serious risks, particularly when misused, according to the Drug Enforcement Administration.

An Overview of the M367 Pill

The M367 pill is commonly prescribed for potent pain relief. It’s a white, capsule-shaped (oblong), and marked with the imprint “M367” on one side. This imprint helps identify the medication, especially when it is found outside of its original prescription bottle.

The pill contains a combination of two active ingredients for effective pain relief: hydrocodone bitartrate (10 mg) and acetaminophen (325 mg).

Hydrocodone is a semi-synthetic opioid that works by binding to receptor sites, especially in the brain and nervous system, to block pain signals. It also produces relaxation and euphoria, which is part of what makes it prone to abuse.

Acetaminophen is a non-opioid pain reliever. It enhances the effectiveness of hydrocodone while helping reduce inflammation and discomfort.

Together, these ingredients are prescribed to treat moderate to severe pain, including injury-related pain that doesn’t respond to less potent medications.

The M367 pill is usually dispensed as a generic version of Norco, which is a well-known brand name in opioid combination medications.

Although its medical uses are legitimate, the M367 pill is frequently misused for its opioid effects, leading to dependency and addiction.

How Does Hydrocodone Work?

Hydrocodone, the main ingredient found in the hydrocodone M367 pill, is a potent opioid medication. It relieves pain by attaching to mu-opioid receptors located in the brain and spinal cord, key components of the body’s internal pain management system.

When these receptors are activated, they not only dull the sensation of pain but also create a calming, sometimes euphoric effect.

This dual action is why hydrocodone is frequently prescribed to treat pain that’s moderate to severe, particularly after surgery or injury.

In addition to pain relief, hydrocodone also causes sedation and a sense of euphoria, especially when taken in higher doses. This euphoric effect plays a major role in its addiction potential, as it can lead to repeated use not just for pain, but for emotional relief or escape.

Side Effects and Dangers of the M367 Pill

While the M367 pill can help with managing pain, it also comes with side effects and serious health risks, especially when misused or taken for an extended period.

Common side effects of the M367 pill include nausea, drowsiness, dizziness, and constipation. These symptoms are typical of opioids and may lessen over time as the body adjusts to the medication.

However, even mild side effects can interfere with daily functioning and elevate the risk of accidents or injury, particularly in older adults.

More serious effects can include respiratory depression, which occurs when breathing slows to dangerously low levels. This can be life-threatening, especially at high doses or when the pill is taken with other central nervous system (CNS) depressants like alcohol, benzodiazepines, or sleep aids.

Additionally, because the M367 pill contains acetaminophen, excessive or prolonged use can cause liver damage, especially when combined with alcohol. Other serious reactions include confusion, mood changes, or slowed heart rate.

Long-term use of the M367 pill significantly increases the risk of developing tolerance and physical and psychological dependence. As tolerance builds, a person may take higher doses to get the same effects, leading to a dangerous cycle that often ends in addiction or overdose.

Due to the risks involved, the M367 pill should only be used under the close supervision of a medical professional. It should never be mixed with alcohol or other sedatives to ensure safety.

Signs of Misuse or Addiction

Recognizing the signs of opioid misuse early can be the key to preventing full-blown addiction. Whether it’s the M367 pill or hydrocodone M366, another formulation of hydrocodone and acetaminophen, both carry a high risk of dependency, even for people who began taking them with a legitimate prescription.

Addiction (opioid use disorder) often develops gradually, but there are several red flags to watch for:

  • Taking higher doses or using the medication more often than prescribed
  • Continuing use after the original medical need is gone
  • “Doctor shopping” or visiting multiple providers for extra prescriptions
  • Being secretive or defensive about pill use
  • Sudden mood changes like irritability, agitation, or emotional withdrawal
  • Physical signs such as pinpoint pupils, drowsiness, slurred speech, and poor coordination
  • Frequently requesting early refills or claiming to have lost prescriptions
  • Intense cravings, anxiety, or restlessness when not using the drug
  • Using the medication to cope with stress, sadness, or everyday problems
  • Becoming unable to function without it over time

If you notice these signs in yourself or someone you care about, it’s crucial to seek help. Early intervention can prevent serious consequences.

What to Do If You or a Loved One Is Abusing the M367 Pill

If you suspect that you or someone you care about is misusing the M367 pill, intervening early is crucial. The longer opioid misuse continues, the higher the risk of addiction, overdose, and long-term health consequences. Early intervention can prevent these serious consequences.

Talking to a loved one about prescription opioid abuse can be challenging, but it’s an essential first step. Many people struggling with addiction can feel ashamed or afraid to ask for help, reassure them that they are not alone and that effective support is available.

Professional treatment for hydrocodone addiction can provide the tools needed for lasting recovery.

Treatment Options for Hydrocodone Addiction in New Jersey

If you or someone close to you is battling an addiction to the M367 pill, it’s vital to seek professional support.

Prescription opioid addiction can develop quickly and intensify without proper intervention, but effective treatment options in New Jersey make recovery possible at any stage.

Whether you’re looking for detox services, residential care, or outpatient support, we’re here to help you take the next step toward overcoming addiction to M367 or hydrocodone M357 and reclaiming your life.

FAQs About the M367 Pill

1. Is the M367 pill the same as Norco?

Not exactly. The M367 pill is a generic version of Norco, containing the same active ingredients: 10 mg of hydrocodone and 325 mg of acetaminophen.

While generics and brand-name drugs must meet the same FDA standards for effectiveness and safety, they can have different inactive ingredients, like binders or fillers, which may slightly affect how a person tolerates the medication.

For most people, M367 will work the same as Norco, but some may notice a difference in how it feels or how long it lasts. If you’ve switched from Norco to M367 and see changes in side effects or effectiveness, speak with your doctor.

2. Can the M367 pill show up on a drug test?

Yes. The M367 pill contains hydrocodone, an opioid that is easily detected in standard drug screenings. Urine tests are the most common. They can detect hydrocodone for up to 2–4 days after use.

Saliva tests may show positive results within hours and last up to 36 hours, while hair follicle tests can detect hydrocodone for up to 90 days.

If you’re taking this medication legally and have a prescription, be sure to disclose it before a drug test to avoid complications.

3. Is it safe to drive after taking the M367 pill?

No, it’s not recommended. The M367 pill contains hydrocodone, a central nervous system depressant that can cause drowsiness, slowed reaction time, and impaired judgment, all of which make driving dangerous.

Even if you feel alert, your coordination and decision-making may still be affected. Operating machinery and driving under the influence of opioids, even if prescribed, can be legally risky and physically dangerous.

Wait until you know how the medicine affects you and talk to your doctor about safe timing before driving.

4. Can I take the M367 pill with other medications?

It depends on the medications. The M367 pill should be taken with caution if you are also using benzodiazepines, muscle relaxants, antidepressants, sleeping pills, or alcohol, as these substances can interact dangerously with hydrocodone.

Combining medicines that cause respiratory depression increases the risk of respiratory depression, which can be a life-threatening medical emergency.

Always let your healthcare provider know about all medications and supplements you’re taking before starting M367. Never mix it with alcohol or other sedatives without medical guidance.

5. What should I do if I accidentally take too much of the M367 pill?

If you think you’ve taken too much, especially more than one dose at a time or too close together, seek medical attention immediately.

Signs of an opioid overdose can include extreme drowsiness, shallow breathing, slow heart rate, cold or clammy skin, and loss of consciousness. Because the M367 pill also contains acetaminophen, high doses can cause severe liver damage, even if opioid symptoms are not obvious.

Call 911 or go to the nearest emergency room if you suspect an overdose.

References:

  1. Medline Plus: Hydrocodone
  2. Science Direct: Hydrocodone versus codeine in acute musculoskeletal pain
  3. National Institute of Health (NIH): Hydrocodone and Acetaminophen
  4. NIH: Hydrocodone
  5. Harvard Health Publishing: Acetaminophen safety: Be cautious but not afraid

Medically Reviewed: May 11, 2025

Dr Ashley

Medical Reviewer

Chief Editor

About

All of the information on this page has been reviewed and verified by a certified addiction professional.

Dr Ashley Murray obtained her MBBCh Cum Laude in 2016. She currently practices in the public domain in South Africa. She has an interest in medical writing and has a keen interest in evidence-based medicine.


All of the information on this page has been reviewed and verified by a certified addiction professional.